Platform hero image

Platform Publications

Delivering on the RNA Revolution

Antibody Oligonucleotide Conjugates (AOC) therapeutics are designed to combine the proven technology of monoclonal antibodies (mAbs) with the precision and potency of oligonucleotide therapies to access previously untreatable tissue and cell types, opening new potential treatments for patients. We have done the experiments and have followed the data to build our AOC platform. We are revolutionizing the RNA therapeutics field by delivering oligonucleotides where they are needed – including beyond the liver.

Publications

Journal of Medicinal Chemistry
Michael Cochran, Isaac Marks, Tyler Albin, Danny Arias, Philip Kovach, Beatrice Darimont, Hanhua Huang, Usue Etxaniz, Hae Won Kwon, Yunyu Shi, Matthew Diaz, Olecya Tyaglo, Arthur Levin, and Venkata Ramana Doppalapudi. Journal of Medicinal Chemistry 2024 67 (17), 14868-14884. DOI: 10.1021/acs.jmedchem.4c00803

Journal of Medicinal Chemistry
Michael Cochran, Danny Arias, Rob Burke, David Chu, Gulin Erdogan, Michael Hood, Philip Kovach, Hae Won Kwon, Yanling Chen, Michael Moon, Christopher D. Miller, Hanhua Huang, Arthur Levin, and Venkata Ramana Doppalapudi. Journal of Medicinal Chemistry 2024 67 (17), 14852-14867. DOI: 10.1021/acs.jmedchem.4c00802

Nucleic Acids Research
Barbora Malecova, Rob S Burke, Michael Cochran, Michael D Hood, Rachel Johns, Philip R Kovach, Venkata R Doppalapudi, Gulin Erdogan, J Danny Arias, Beatrice Darimont, Christopher D Miller, Hanhua Huang, Andrew Geall, Husam S Younis, Arthur A Levin. Nucleic Acids Research, 2023;, gkad415, https://doi.org/10.1093/nar/gkad415

The New England Journal of Medicine
Levin, AA. N Engl J Med 2017;376:1DOI 10.1056/NEJMcibr1613559

The New England Journal of Medicine
Levin, AA. N Engl J Med 2019;380:1DOI: 10.1056/NEJMra1705346

Presentations

2025 MDA Clinical and Scientific Conference

AHA Scientific Sessions 2024

2024 World Muscle Society Congress

2024 NMSG 25TH Annual Scientific Meeting

2024 FSHD Society International Research Congress

2024 International Myotonic Dystrophy Consortium Meeting

2024 MDA Clinical and Scientific Conference

2023 World Muscle Society Congress

2023 NMSG 24TH Annual Scientific Meeting

2023 Myotonic Dystrophy Foundation Annual Conference

2023 International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Conference

2023 75th AAN Annual Meeting

2023 MDA Clinical and Scientific Conference

2023 AMCP Annual Meeting

2022 World Muscle Society Congress

2022 FSHD Society International Research Congress

2022 74th AAN Annual Meeting

2022 MDA Clinical and Scientific Conference

2021 MDA Virtual Clinical and Scientific Conference

2021 AAN Annual Meeting

2021 FSHD Society IRC Annual Meeting