Careers

World Class Team

At Avidity Biosciences, we recognize that the success of our business depends on the excellence of our people.

At Avidity, we are pioneers. We are blazing a new trail in oligonucleotide-based therapies. We enjoy working with like-minded individuals who are intellectually curious, disciplined, and passionate about helping patients in need.

With this in mind, we are highly vested in the recruitment, training and development of our employees. We are looking for exceptional people who are aligned with our mission and are interested in being a part of a team that is committed to developing a pipeline of innovative AOCs to treat serious unmet medical needs.

Job Opportunities

    • Job Title: Research Associate, In Vitro Biology
    • Location: La Jolla, CA
    • Employee Status: Full time
    • Travel: No

    Role:

    We are seeking an energetic BS/MS level research associate with a background in immunology and cellular biology to develop novel therapeutic antibody-targeted conjugates that deliver nucleic acids such as therapeutic siRNAs to immune cells. This is a hands-on position and the ideal candidate will have 3+ years of experience in Biotech/Biopharma with a proven record of immune cell assay development, producing exceptional results in tissue culture and processing of animal tissues and other lab procedures.

    Responsibilities:

    • Hands-on experience with cell culture of human and rodent immune cells, processing animal tissues, RNA isolation, quantitative real-time PCR and immunohistochemistry
    • Experience in assay development, using multiple molecular and cellular techniques such as qPCR, flow cytometry, and cytokine measurements, in preclinical and clinical samples, is highly desired
    • Excellent data analysis and problem-solving skills
    • Strong organizational skills including the ability to manage several studies simultaneously
    • Critical thinking and ability to analyze and present data
    • Show initiative and have the ability to work independently and in a project team-oriented environment

    Requirements:

    • MS degree in the biological sciences with 3+ years (or BS with 5 years) of relevant drug discovery experience

    Apply Now
    • Job Title: Research Associate I/II, DMPK
    • Location: La Jolla, CA
    • Employee Status: Full time
    • Travel: No

    Role:

    We are seeking a Research Associate to join the Drug Metabolism & Pharmacokinetics (DMPK) team at Avidity Biosciences in La Jolla, CA. This position will require hands-on lab work with responsibility for processing and analyzing animal blood and tissues, RNA isolation, quantitative RT-PCR, ELISA, Nanostring, mammalian cell culture, western blot, chromatography (RP-HPLC, SAX, SEC, etc), and pharmacokinetic analysis. Prior experience and a high degree of proficiency with these techniques are required.

    Responsibilities:

    • Design and perform experiments, analyze experimental data, interpret and report results, provide feedback on appropriate next steps such as assay optimization or follow-up experiments
    • Collaborate and communicate across departments, participate on drug development project teams, provide DMPK expertise to advance research programs
    • Demonstrate effective presentation and verbal communication at internal meetings as well as clear written communication

    Requirements:

    • BS or MS in Bioengineering, Chemistry, Biology, or related discipline
    • Prior hands-on lab experience with various laboratory techniques including RNA isolation, qPCR, ELISA, Nanostring, cell culture, western blot, and HPLC
    • Ability to conduct self-directed research and to work effectively in a dynamic environment with a diverse team of coworkers
    • Solid written and oral communication skills, enthusiasm, integrity, exceptional problem-solving skills, self-motivation, strong interpersonal skills, and attention to detail are necessary

    Apply Now
    • Job Title: Vice President, Regulatory and Quality Assurance
    • Location: La Jolla, CA
    • Employee Status: Full time
    • Travel: No

    Role:

    The Vice President, Regulatory and Quality Assurance will join the executive management team and assist in the development and implementation of strategies, business plan, budget, and works plans to achieve company’s vision and mission. The position will provide leadership for all Regulatory and Quality activities to drive product development programs and ensure the Company’s ongoing compliance with regulatory mandates. Oversee the company’s regulatory activities and initiatives, assure the quality of products and processes, and ensure the highest integrity in regulatory and quality compliance. Will lead teams to strategize product development plans and advise department leaders of regulatory considerations in-light-of the Company’s goals and overseeing all aspects of submissions to regulatory authorities. Must be a dynamic leader with outstanding communication, strategic and collaboration skills, and will provide adept supportive leadership.

    Responsibilities:

    Specific Regulatory Responsibilities include:
    • Serve as the primary corporate interface for all regulatory authorities, both within and outside the U.S.
    • Identify required or advisable regulatory submissions, both within and outside the U.S. based on corporate objectives; establish timelines for preparing, reviewing, and finalizing submissions.
    • Develop document templates to assist individual functional groups with responsibility for drafting substantive content; coordinating with multiple groups to maintain submission timelines, providing final review to ensure internal consistency, satisfaction of regulatory requirements, corporate objective(s), and overall “fitness for purpose”.
    • Responsible for defining requirements for writing, editing, final review and approval of reports and regulatory submissions.
    • Accountable for the accuracy of regulatory submissions, and communications with Regulatory Agencies.
    • Participate in internal cross-functional group meetings and providing regulatory input in multiple areas, including clinical study design and endpoints; preclinical pharmacology and toxicology; and CMC.
    • Responsible for organizational policies and standards to maintain corporate regulatory compliance and maintains responsibility for the implementation of such policies and procedures.
    • Develop and implement a departmental budget that meets all corporate and regulatory goals and requirements.
    • Review Final Study Reports, manufacturing process documentation, Investigator Brochures, Clinical Study Protocols, and clinical trial documentation for compliance with cGCPs, cGMPs, cGLPs and other regulations and guidelines.
    • Communicate changing regulatory requirements with senior management throughout the company.
    • Stay current with regulatory developments relevant to the Company’s programs.
    • Advise senior management, including making recommendations regarding tactical and strategic considerations in the context of corporate goals and identifying changes and trends within regulatory bodies, both within and outside the U.S.
    • Establish a network of relationships with key national and international regulators/regulatory agencies; interacts with key scientific, clinical research, marketing and commercial personnel internally and externally to ensure timely and accurate regulatory compliance.
    • Defines and establishes regulatory strategies for product development efforts and works closely with research and clinical development.
    • Ensures that CMC and clinical trial protocols are properly designed to comply with current regulatory guidelines.
    • Accountable for timely adverse event reporting to regulatory activities.
    • Perform other duties as required.

    Specific Quality Assurance Responsibilities include:
    • Manages and directs QA personnel responsible for GMP oversight of API and drug products produced at contract manufacturing sites, as well as applicable GCP and GLP study sites. Includes resource planning, prioritization of resources and projects.
    • Directs a wide variety of activities to ensure compliance with quality systems, quality procedures, quality policies and applicable regulatory requirements to facilitate compliance with regulatory agencies and business requirements.
    • Develops and implements and maintains programs/processes to ensure high quality products and compliance with cGMP.
    • Responsibilities include the final release of commercial API and drug product for global markets.
    • Directs and mentors’ staff in complex technical complaints, investigations, regulatory agency correspondence and recall management.
    • Represents company as host of regulatory GMP inspections at applicable contract site and supports inspections at CMO facilities.
    • Works with Pharmaceutical Development and Manufacturing teams during technology transfer of new product start-ups, establishing key checkpoints for new products and processes, and managing change implementation.
    • Develops and implements a departmental budget that meets all corporate and quality assurance goals and requirements.
    • Directs compliance audits as required.
    • Reviews and approves regulatory submissions.
    • Interfaces with regulatory agencies as required representing the company to authorities and regulatory inspectorates.
    • Reviews, approves, and directs implementation of changes to controlled documents and processes (e.g., SOPs, Specifications, Methods, etc.) as needed.
    • Perform other duties as required.

    Desired Knowledge and Abilities:
    • Experience in all phases of regulatory submissions and interactions, including post-approval experience; international experience also required, along with direct contact and negotiation experience with the FDA.
    • Rare disease experience a plus.
    • Experience in leading the Quality function for a biopharmaceutical company and familiarity with GxPs.
    • Experience with electronic filing and database management abilities.
    • Experience with documentation systems and with document review and auditing.
    • Excellent communication skills, team member that can work collaboratively with colleagues across all functions.
    • Excellent analytical, presentation, writing, and computer skills are required.
    • Comprehensive knowledge of current US and ex-US regulatory guidelines.
    • Demonstrate excellent leadership and communication skills.
    • Demonstrate strong organizational skills, including the ability to prioritize personal workload.
    • Extensive supervisory experience and ability to guide, train, supervise and prioritize workload of direct reports.
    • Senior managerial experience in a small company environment is desirable.
    • Ability to work well in a deadline-driven environment.
    • Capable of supporting multiple projects simultaneously.

    Requirements:

    • Bachelor’s degree Life/Health Sciences; Master’s degree and/or Ph.D. a plus
    • Minimum of 20 years of experience in pharmaceutical / biotech
    • Minimum 15 years in a management role within Regulatory / Quality Assurance

    Apply Now
    • Job Title: Scientist/Sr. Scientist, Analytics and Formulations
    • Location: La Jolla, CA
    • Employee Status: Full time
    • Travel: No

    Role:

    We are seeking a Scientist/Senior Scientist, Analytics & Formulations, to join our team in La Jolla. This is a hands-on position with responsibility for the analysis of antibody oligonucleotide conjugates (AOCs) as well as for development and optimization of AOC formulations. The ideal candidate will have experience in pharmaceutical sciences, ideally including antibodies and nucleic acid therapeutics. The candidate is expected to be a strong team player who enjoys scientific discovery and can communicate and collaborate in a fast-paced interdisciplinary environment.

    Responsibilities:

    • Development and implementation of both routine and novel assays for the characterization of AOCs as well as antibodies and oligonucleotides
    • Optimization and exploration of formulation conditions for antibodies and AOCs
    • Assay development for novel targets as well as to answer mechanistic questions
    • Preparation and communication of research results in both oral and written formats

    Requirements:

    • Ph.D. in biochemistry, bioengineering, or similar with hands-on laboratory experience
    • Thorough knowledge of plate- and HPLC- based characterization assays for biologics
    • Previous experience in biotech/pharma is desirable
    • Proven ability to conduct self-directed research, and to work effectively in a dynamic environment with a diverse team of co-workers
    • Solid written and oral communication skills, enthusiasm, integrity, self-motivation, strong interpersonal skills, and attention to detail are necessary

    Apply Now
    • Job Title: Director, Clinical Development
    • Location: La Jolla, CA
    • Employee Status: Full time
    • Travel: No

    Role:

    The Director, Clinical Development will work with key internal and external stakeholders to develop and execute clinical development plans (CDPs). This position will collaborate with clinical operations, regulatory, data management and other groups as appropriate for study implementation along with overseeing the interpretation and dissemination of study results and related publications. They will serve as a core member of the clinical development team, contributing to the overall clinical strategy, providing guidance and direction to the team to ensure successful achievement of program goals and milestones and to ensure all activities occur in compliance with the appropriate regulations and ICH/GCP.

    Responsibilities:

    • Support Senior Management in providing scientific/medical input into the design of the CDP for investigational products in all phases of development.
    • Responsible and accountable for scientific validity and integrity of the CDP and all clinical content, including writing and editing of protocols, IBs/, clinical data reviews, CSRs, regulatory submissions, and publications associated with the clinical trials.
    • Responsible for developing and implementing study protocols in conjunction with the clinical development team.
    • Collaborate and provide scientific input on development of informed consent forms (ICF), case report forms (CRFs), statistical analysis plans (SAPs), study manuals and other clinical trial documents.
    • Oversee clinical trial conduct in conjunction with clinical operations including vendors, CRO’s and KOL’s.
    • Participate in ongoing review of clinical data including protocol deviations.
    • Lead development of clinical biomarker strategies for early development.
    • Analyze, interpret, and present results of clinical studies to include manuscripts, abstracts, and posters.
    • Maintain scientific and clinical knowledge in the relevant therapeutic and disease area(s).
    • Communicate to management and relevant functions any potential issues or risks (e.g., changes or significant risks to the Clinical Development Plan, new safety concerns) in a timely manner.
    • Contribute to key cross-functional and clinical meetings (e.g., investigator meetings, ad hoc meetings, scientific focus, or steering committee meetings).
    • Identify potential collaborators and investigators.
    • Consistently complies with regulations, ICH/GCP and company SOPs.
    • Perform other duties as required.

    Desired Knowledge and Abilities:
    • Rare disease experience a plus.
    • Ability to assimilate technical and scientific information and proficient at data interpretation.
    • Knowledge of clinical trial design and in-depth understanding of Phase 1 through 4 drug development.
    • Knowledge of FDA and EMEA guidelines.
    • Experience writing all types of clinical & regulatory documents and familiarity with registration dossiers
    for worldwide use.
    • Skilled in use of MS WORD, Excel, and Power Point.
    • Excellent interpersonal, communication, and presentation skills (written and verbal)
    • Demonstrate strong organizational skills, including the ability to prioritize personal workload.
    • Supervisory experience and ability to guide, train, supervise and prioritize workload of direct reports.
    • Ability to work well in a deadline-driven environment.
    • Capable of supporting multiple projects simultaneously.
    • Ability to work on cross-functional teams.

    Requirements:

    • PhD, PharmD or MD required
    • Minimum of 6 years of experience in pharmaceutical / biotech in clinical sciences and clinical drug development

    Apply Now

Notice to Recruiters & Staffing Agencies

Recruiters and staffing agencies should not contact Avidity Biosciences through this page. We require that all recruiters and staffing agencies have a signed contract on file. Any resumes submitted through the website or directly by recruiters or staffing agencies will be considered unsolicited and the company will not be responsible for any related fees.